On February 13, 1861, the hospital opened its doors to admit patients suffering from fever, scabies, and venereal diseases, as well as wounded soldiers of the French-Spanish coalition forces transferred from the Battle of Ky Hoa Fortress (February 24–25, 1861), followed by wounded soldiers from battles across Saigon-Gia Dinh and the Southern region.
– Following the country's reunification, the hospital was taken over and managed by the Southern Social Health Committee, reclaiming its name as Cho Quan Hospital.
– On August 4, 1979, pursuant to Decision No. 903 issued by the Ministry of Health, Cho Quan Hospital was assigned the role of a specialized hospital for infectious diseases, responsible for treatment, epidemic prevention and control, as well as specialized training for Ho Chi Minh City and the southern provinces.
– In 1989, the People's Committee of Ho Chi Minh City decided to rename the hospital the Center for Tropical Diseases under the Department of Health.
– In 1996, the hospital was classified as a Grade 1 hospital, specializing deeply in infectious diseases for Ho Chi Minh City and the southern provinces.
– In 2002, the hospital was renamed the Hospital for Tropical Diseases and has continued to make significant contributions to the construction and development of the field of infectious and tropical diseases in the southern provinces.
– The journey starting from its opening day on February 13, 1861, marked a historic milestone in the nation's medical history, establishing a record for the Hospital for Tropical Diseases as the oldest hospital in Vietnam, officially recognized by the Vietnam Records Organization (under the Vietnam Record Association).
– The hospital has been honored with numerous prestigious medals and titles: First-Class Labor Order (2007), Third-Class Independence Order (2012), Hero of Labor (2015), Third-Class Labor Order (2021), and many Certificates of Merit from the Municipal People's Committee.